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Expedient Synthesis of 1,4‐Benzodiazepines via a Tandem Condensation/[1,5]‐Hydride Transfer/Cyclization Process
Author(s) -
Liu Siyuan,
Zhao Tuan,
Qu Jingping,
Wang Baomin
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800781
Subject(s) - chemistry , tandem , benzaldehyde , hydride , condensation , combinatorial chemistry , atom economy , process (computing) , transformation (genetics) , organic chemistry , catalysis , aerospace engineering , programming language , hydrogen , biochemistry , physics , computer science , gene , thermodynamics , engineering
An expedient approach to 1,4‐benzodiazepines via a tandem condensation/[1,5]‐hydride shift/cyclization process has been developed. This transformation started from readily available o ‐amino benzaldehyde and aminomalonate and was promoted by low‐cost FeCl 3 with high step and atom economy.