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An Atropos Biphenyl Bisphosphine Ligand with 2,2′‐ tert ‐Butylmethylphosphino Groups for the Rhodium‐Catalyzed Asymmetric Hydrogenation of Enol Esters
Author(s) -
Jia Jia,
Fan Dongyang,
Zhang Jian,
Zhang Zhenfeng,
Zhang Wanbin
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800774
Subject(s) - chemistry , stereocenter , biphenyl , ligand (biochemistry) , asymmetric hydrogenation , rhodium , enol , catalysis , stereochemistry , crystal structure , enantioselective synthesis , medicinal chemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry
This is an update of our previous work concerning the development of Atropos biphenyl bisphosphine ligands. An unexpected Atropos structural property was confirmed by single crystal X‐ray diffraction and this result is consistent with the computational calculations described in our previous work. This P‐stereogenic bisphosphine ligand possessing a biphenyl backbone and 2,2′‐ tert ‐butylmethylphosphino groups has been applied to the Rh‐catalyzed asymmetric hydrogenation of enol esters, which has not been widely studied and can be used for the synthesis of several important bioactive compounds. Although there is room for further improvement in enantioselectivity, the results reported herein provide a further understanding of such types of ligands.