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Ru (II)‐Catalyzed Coupling‐Cyclization of Sulfoximines with alpha ‐Carbonyl Sulfoxonium Ylides as an Approach to 1,2‐Benzothiazines
Author(s) -
Xie Haisheng,
Lan Jianyong,
Gui Jiao,
Chen Fengjuan,
Jiang Huangfeng,
Zeng Wei
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800753
Subject(s) - chemistry , aryl , catalysis , coupling (piping) , medicinal chemistry , benzothiazine , combinatorial chemistry , stereochemistry , organic chemistry , alkyl , mechanical engineering , engineering
Abstract A Ru(II)‐catalyzed approach for the rapid assembly of 1,2‐benzothiazines has been developed to enable the coupling‐cyclization of aryl C sp 2 −H bonds with α‐carbonyl sulfoxonium ylides via C sp 2 −H activation process. The present method could be further applied to the construction of the 4‐substituted 1,2‐benzothiazine skeletons.