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Visible Light‐Mediated Trifluoromethylation of Fluorinated Alkenes via C−F Bond Cleavage
Author(s) -
Wu LiuHai,
Cheng JunKee,
Shen Liang,
Shen ZhiLiang,
Loh TeckPeng
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800740
Subject(s) - trifluoromethylation , chemistry , trifluoromethyl , fluorine , stereoselectivity , photoredox catalysis , bond cleavage , photochemistry , cleavage (geology) , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , photocatalysis , alkyl , geotechnical engineering , fracture (geology) , engineering
A convenient photoredox‐catalyzed defluorinative trifluoromethylation of α ‐trifluoromethyl alkenes and gem ‐difluoroalkenes is developed. The reactions proceeded efficiently via trifluoromethyl radical addition followed by β ‐fluorine elimination process, providing a new entry to multifluorinated alkenes in moderate to good yields with excellent stereoselectivity.