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Direct Reduction of Allylic Alcohols Using Isopropanol as Reductant
Author(s) -
Sai Masahiro
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800731
Subject(s) - chemistry , allylic rearrangement , acetone , lithium (medication) , hydride , reduction (mathematics) , catalysis , organic chemistry , inorganic chemistry , metal , geometry , mathematics , medicine , endocrinology
The lithium cation‐catalyzed direct reduction of allylic alcohols to alkenes using isopropanol as a hydride donor was developed. The hydride transfer of the in situ‐generated lithium isopropoxide to an allylic cation is the key process in this transformation. The reaction generates only water and acetone as byproducts, which highlights the synthetic utility of this method.