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Front Cover Picture: One‐Pot Synthesis of Fused N,O ‐Heterocycles through Rh(III)‐Catalyzed Cascade Reactions of Aromatic/Vinylic N ‐Alkoxy‐ Amides with 4‐Hydroxy‐2‐Alkynoates (Adv. Synth. Catal. 14/2018)
Author(s) -
Xu Yuanshuang,
Li Bin,
Zhang Xinying,
Fan Xuesen
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800725
Subject(s) - chemistry , annulation , regioselectivity , oxidizing agent , catalysis , amide , cascade , rhodium , alkoxy group , cascade reaction , medicinal chemistry , substrate (aquarium) , stereochemistry , organic chemistry , alkyl , chromatography , oceanography , geology
The front cover picture , provided by Xuesen Fan and co‐workers, illustrates a rhodium(III)‐catalyzed cascade reaction of vinylic N ‐alkoxyamides with 4‐hydroxy‐2‐alkynoates leading to the regioselective formation of furo[3,4‐ b ]pyridine‐2,5(1 H ,7 H )‐diones. Notably, this cascade process is triggered by an inert C( sp 2 )−H bond activation of the amide substrate followed by its [4+2] annulation and lactonization with 4‐hydroxy‐2‐alkynoate featuring with an oxidizing and partially traceless directing group. Details can be found in the communication on pages 2613–2620 (Y. Xu, B. Li, X. Zhang, X. Fan, Adv. Synth. Catal . 2018 , 360 , 2613–2620; DOI: 10.1002/adsc.201800190).