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Cover Picture: Rhodium(I)‐Catalyzed Azide‐Alkyne Cycloaddition (RhAAC) of Internal Alkynylphosphonates with High Regioselectivities under Mild Conditions (Adv. Synth. Catal. 13/2018)
Author(s) -
Song Wangze,
Zheng Nan,
Li Ming,
Ullah Karim,
Zheng Yubin
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800722
Subject(s) - cycloaddition , chemistry , regioselectivity , alkyne , rhodium , azide , catalysis , combinatorial chemistry , click chemistry , substrate (aquarium) , functional group , stereochemistry , organic chemistry , oceanography , polymer , geology
The inside cover picture , provided by Wangze Song, Nan Zheng and co‐workers, illustrates a regioselective method to access fully substituted 1,2,3‐triazolyl‐4‐phosphonates from the internal alkynylphosphonates by a rhodium(I)‐catalyzed azide‐alkyne cycloaddition (RhAAC) under mild conditions. This approach is water‐ and air‐compatible and has a broad substrate scope, good functional group tolerance, and affords high yields as well as excellent regioselectivities. The gram‐scale preparation, application to carbohydrate synthesis, and the solid‐phase synthesis of triazolyl‐4‐phosphonates are highlights of this method. Details can be found in the communication on pages 2429–2434 (W. Song, N. Zheng, M. Li, K. Ullah, Y. Zheng, Adv. Synth. Catal . 2018 , 360 , 2429–2434; DOI: 10.1002/adsc.201800336).