Copper‐Catalyzed [4+2] Cycloaddition Using  N ‐(2‐Pyridyl)ketimines and Terminal Alkynes | Zendy

Tatsumi Kenta | Zendy; Fujihara Tetsuaki | Zendy; Terao Jun | Zendy; Tsuji Yasushi | Zendy

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Copper‐Catalyzed [4+2] Cycloaddition Using N ‐(2‐Pyridyl)ketimines and Terminal Alkynes

Author(s) -

Tatsumi Kenta,

Fujihara Tetsuaki,

Terao Jun,

Tsuji Yasushi

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201800704

Subject(s) - chemistry , cycloaddition , catalysis , copper , terminal (telecommunication) , trifluoromethyl , medicinal chemistry , organic chemistry , polymer chemistry , telecommunications , alkyl , computer science

Copper‐catalyzed [4+2] cycloaddition of N ‐(2‐pyridyl)ketimines and terminal alkynes has been achieved. Ketimines bearing a trifluoromethyl group reacted with various terminal alkynes to produce pyrido[1,2‐ a ]pyrimidines in good to high yields. This reaction proceeded through a propargylamine intermediate and the corresponding product was obtained via 6‐endo‐dig cyclization.

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