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Copper‐Catalyzed [4+2] Cycloaddition Using N ‐(2‐Pyridyl)ketimines and Terminal Alkynes
Author(s) -
Tatsumi Kenta,
Fujihara Tetsuaki,
Terao Jun,
Tsuji Yasushi
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800704
Subject(s) - chemistry , cycloaddition , catalysis , copper , terminal (telecommunication) , trifluoromethyl , medicinal chemistry , organic chemistry , polymer chemistry , telecommunications , alkyl , computer science
Copper‐catalyzed [4+2] cycloaddition of N ‐(2‐pyridyl)ketimines and terminal alkynes has been achieved. Ketimines bearing a trifluoromethyl group reacted with various terminal alkynes to produce pyrido[1,2‐ a ]pyrimidines in good to high yields. This reaction proceeded through a propargylamine intermediate and the corresponding product was obtained via 6‐endo‐dig cyclization.