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Iron‐Catalyzed Synthesis of Substituted Thiazoles from Enamines and Elemental Sulfur through C−S Bond Formation
Author(s) -
Wu Mingzhong,
Jiang Yong,
An Zhenyu,
Qi Zhenjie,
Yan Rulong
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800693
Subject(s) - chemistry , sulfur , catalysis , elemental analysis , surface modification , organic chemistry , atom (system on chip) , organic synthesis , combinatorial chemistry , computer science , embedded system
An atom economical approach for the synthesis of substituted thiazoles starting from enamines and elemental sulfur through the C−H functionalization/C−S bond formation is described. Under the optimized conditions, various substituted enamines reacted smoothly with elemental sulfur and the desired substituted thiazoles were generated in moderate to excellent yields.