Premium
Palladium‐Catalyzed Domino Heck/Silylation Reaction for the Synthesis of (2‐Oxoindolin‐3‐yl)methylsilanes via Trapping of the σ‐Alkylpalladium Intermediates with Disilanes
Author(s) -
Xiao Genhua,
Chen Liang,
Zhou Bang,
Deng Guobo,
Gong Jun,
Liang Yun
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800687
Subject(s) - domino , chemistry , silylation , palladium , catalysis , heck reaction , combinatorial chemistry , organic chemistry
A palladium‐catalyzed domino Heck/silylation reaction of acrylamides with hexamethyldisilane is presented. This transformation, which involves the formation of a σ‐alkylpalladium intermediate, allows direct access to functionalized (2‐oxoindolin‐3‐yl)methylsilanes in good to excellent yields. Furthermore, this strategy could be utilized for the synthesis of (2‐oxoindolin‐3‐yl)methylstannanes from hexamethyldistannane.