Palladium‐Catalyzed Domino Heck/Silylation Reaction for the Synthesis of (2‐Oxoindolin‐3‐yl)methylsilanes  via  Trapping of the σ‐Alkylpalladium Intermediates with Disilanes | Zendy

Xiao Genhua | Zendy; Chen Liang | Zendy; Zhou Bang | Zendy; Deng Guobo | Zendy; Gong Jun | Zendy; Liang Yun | Zendy

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Palladium‐Catalyzed Domino Heck/Silylation Reaction for the Synthesis of (2‐Oxoindolin‐3‐yl)methylsilanes via Trapping of the σ‐Alkylpalladium Intermediates with Disilanes

Author(s) -

Xiao Genhua,

Chen Liang,

Zhou Bang,

Deng Guobo,

Gong Jun,

Liang Yun

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201800687

Subject(s) - domino , chemistry , silylation , palladium , catalysis , heck reaction , combinatorial chemistry , organic chemistry

A palladium‐catalyzed domino Heck/silylation reaction of acrylamides with hexamethyldisilane is presented. This transformation, which involves the formation of a σ‐alkylpalladium intermediate, allows direct access to functionalized (2‐oxoindolin‐3‐yl)methylsilanes in good to excellent yields. Furthermore, this strategy could be utilized for the synthesis of (2‐oxoindolin‐3‐yl)methylstannanes from hexamethyldistannane.

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