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Synthesis of α‐Iodoketones from Allylic Alcohols through Aerobic Oxidative Iodination
Author(s) -
SanzMarco Amparo,
Možina Štefan,
MartinezErro Samuel,
Iskra Jernej,
MartínMatute Belén
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800661
Subject(s) - chemistry , allylic rearrangement , halogenation , isomerization , iodine , oxidative phosphorylation , iridium , catalysis , combinatorial chemistry , organic chemistry , biochemistry
Abstract An efficient method for the synthesis of α‐iodoketones from allylic alcohols and elemental iodine is reported. We show in this paper that the isomerization of allylic alcohols catalyzed by iridium(III) complexes can be combined with an aerobic oxidative iodination protocol, resulting in a straightforward method for the synthesis of a wide range of α‐iodoketones as single constitutional isomers and in high yields under mild reaction conditions.