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Rh(III)‐Catalyzed Selective C8−H Acylmethylation of Quinoline N ‐Oxides
Author(s) -
You Chang,
Pi Chao,
Wu Yangjie,
Cui Xiuling
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800659
Subject(s) - chemistry , quinoline , regioselectivity , catalysis , combinatorial chemistry , oxide , scope (computer science) , transformation (genetics) , atmosphere (unit) , rhodium , medicinal chemistry , organic chemistry , biochemistry , physics , thermodynamics , computer science , gene , programming language
A highly efficient Rh‐catalyzed regioselective C8−H acylmethylation of quinoline N‐ oxides with sulfoxonium ylides using N‐ oxide as the directing group under air atmosphere has been developed. This transformation has the generality of a broad scope of substrates, avoids external oxidants, and provides an efficient protocol to C8−H acylmethylated quinolines.