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Copper‐Catalyzed Asymmetric Ring‐Opening of Cyclic Diaryliodonium with Benzylic and Aliphatic Amines
Author(s) -
Xu Shibo,
Zhao Kun,
Gu Zhenhua
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800637
Subject(s) - chemistry , catalysis , ring (chemistry) , cyclic amines , lewis acids and bases , copper , synergistic catalysis , organic chemistry , polymer chemistry , medicinal chemistry , combinatorial chemistry
A Cu‐catalyzed asymmetric ring‐opening reaction between cyclic diaryliodonium and benzylic or aliphatic amines has been developed. At low concentration of the amines, realized by either mixing the amines with Lewis acid or slow addition of the amines, the reaction afforded the products in high enantioselectivity.