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Iron‐Catalyzed Dehydrogenative Borylation of Terminal Alkynes
Author(s) -
Wei Duo,
Carboni Bertrand,
Sortais JeanBaptiste,
Darcel Christophe
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800588
Subject(s) - borylation , chemistry , dabco , toluene , catalysis , yield (engineering) , octane , terminal (telecommunication) , organic chemistry , medicinal chemistry , combinatorial chemistry , materials science , computer science , aryl , metallurgy , telecommunications , alkyl
Abstract The catalytic system based on Fe(OTf) 2 (2.5 mol%) and DABCO (1 mol%) selectively promotes the dehydrogenative borylation of both aromatic and aliphatic terminal alkynes to afford alkynylboronate derivatives in the presence of 1 equiv. of pinacolborane at 100 °C in toluene. This methodology is applicable to a variety of terminal alkynes (16 examples, yield: 62–93%).