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Unexpected Decarboxylation‐Triggered o ‐Hydroxyl‐Controlled Redox Condensation of Phenylglycines with 2‐Nitrophenols in Aqueous Media
Author(s) -
Tang Lin,
Yang Zhen,
Sun Tian,
Zhang Di,
Ma Xiantao,
Rao Weihao,
Zhou Yuqiang
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800586
Subject(s) - chemistry , decarboxylation , aqueous medium , aqueous solution , redox , condensation , condensation reaction , organic chemistry , photochemistry , combinatorial chemistry , catalysis , physics , thermodynamics
A decarboxylation‐triggered and o ‐hydroxyl‐controlled hydrogen‐transfer strategy for the one‐pot synthesis of benzoxazoles from readily available amino acids and 2‐nitrophenols is reported. On the basis of this autoredox reaction, the C−N bond can be efficiently constructed to afford the desired products in moderate to good yields under transition‐metal‐free conditions in aqueous media.