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Manganese‐Catalyzed C−H Amidation of Heteroarenes in Water
Author(s) -
Kong Xianqiang,
Lin Long,
Xu Bo
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800544
Subject(s) - chemistry , manganese , regioselectivity , metalation , catalysis , electrophile , sulfonyl , functional group , combinatorial chemistry , solvent , organic chemistry , alkyl , polymer
We have developed an efficient manganese‐catalyzed amidation of various heteroarenes via C−H bond activation using readily available sulfonyl azides. The key step is heteroarene directed electrophilic aromatic metalation using MnBr(CO) 5 as catalyst. This method offers excellent chemical yields and regioselectivity with good functional group tolerance. This base metal catalyzed reaction proceeds efficiently using water as the only solvent and nitrogen is the only byproduct.