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Boron Trifluoride‐Mediated Trifluoromethylthiolation of N ‐Acyliminiums
Author(s) -
Maury Julien,
Force Guillaume,
Darses Benjamin,
Lebœuf David
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800514
Subject(s) - boron trifluoride , chemistry , nucleophile , boron , copper , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis
Herein, we describe a hitherto unprecedented trifluoromethylthiolation of N ‐acyliminiums promoted by boron trifluoride etherate to enable a convenient access to various α‐amino trifluoromethylthiolate derivatives in good yields. The reaction proceeds under mild conditions, relying on copper(I) trifluoromethylthiolate as a nucleophilic partner.
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