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Manganese‐Catalyzed C−H Annulation of Ketimines with Allenes: Stereoselective Synthesis of 1‐Aminoindanes
Author(s) -
Lei Chong,
Peng Lijie,
Ding Ke
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800465
Subject(s) - chemistry , stereocenter , annulation , vicinal , manganese , catalysis , stereoselectivity , substrate (aquarium) , selectivity , double bond , stereochemistry , medicinal chemistry , atom economy , organic chemistry , enantioselective synthesis , oceanography , geology
A manganese‐catalyzed C−H annulation of ketimines with poly‐substituted ester‐activated allenes toward the synthesis of 1‐aminoindanes bearing two vicinal all‐substituted carbon stereocenters and an exocyclic double bond was developed. The reaction features high diastereoselectivity, high E / Z selectivity, 100% atom‐economy, broad substrate scope and good functional group tolerance.