Premium
Rhodium‐Catalyzed Tandem Reaction of Isocyanides with Trifluorodiazoethane and Nucleophiles: Divergent Synthesis of Trifluoroethyl‐Substituted Isoquinolines, Imidates, and Amidines
Author(s) -
Bu XiuBin,
Wang Zhuo,
Wang XueDi,
Meng XiangHe,
Zhao YuLong
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800445
Subject(s) - chemistry , nucleophile , rhodium , tandem , substrate (aquarium) , catalysis , functional group , combinatorial chemistry , stereoselectivity , scope (computer science) , reaction conditions , organic chemistry , stereochemistry , materials science , composite material , oceanography , polymer , computer science , programming language , geology
A rhodium‐catalyzed tandem reaction of isocyanides with 2,2,2‐trifluorodiazoethane and various nucleophiles has been developed. The protocol provides a simple and highly efficient method for the construction of trifluoroethyl‐substituted isoquinolines, imidates and amidines with broad substrate scope in good to high yields. These reactions feature readily available starting materials, three‐component, one‐pot procedure, good to high yields, broad substrate scope, good functional group tolerance, and excellent stereoselectivity.