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Copper‐Catalyzed Radical Sulfonylation of N ‐Propargylindoles with Concomitant 1,2‐Aryl Migration
Author(s) -
Zhu XinYu,
Han YaPing,
Li Ming,
Li XueSong,
Liang YongMin
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800414
Subject(s) - chemistry , aryl , propargyl , indole test , catalysis , copper , concomitant , medicinal chemistry , functional group , combinatorial chemistry , stereochemistry , organic chemistry , alkyl , statistics , mathematics , polymer
A novel copper‐catalyzed cascade radical sulfonylation of N ‐propargyl‐substituted indoles with concomitant 1,2‐aryl migration was described. The protocol, which has good functional‐group tolerance, provides practical, versatile and atom‐economical method of accessing a new class of fascinating 2‐sulfonated pyrrolo[1,2‐ α ]indole derivatives in moderate to good yields through the formation of the new C−S, C−C and C=O bonds in a one‐step.