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CO 2 ‐Promoted C=N Bond Cleavage of Amidines Leading to Multi‐Substituted Pyridines
Author(s) -
Liu Jianming,
Yan Xuyang,
Yue Yuanyuan,
Zhao Shufang,
Zhang Jia,
Sun Yangyang,
Zhuo Kelei
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800401
Subject(s) - chemistry , cleavage (geology) , bond cleavage , functional group , combinatorial chemistry , oxygen atom , medicinal chemistry , stereochemistry , catalysis , organic chemistry , molecule , polymer , geotechnical engineering , fracture (geology) , engineering
A practical protocol is developed using carbon dioxide as a promoter for the C=N bond cleavage of amidines. This direct and operationally simple approach afforded parallel library of multi‐functional pyridines under the mild condition. The mechanistic isotope labeling experiment suggested that the oxygen atom of resulting carbonyl group was originated from water.