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Cobalt‐Catalyzed Directed sp 2 C−H Acetoxylation of Arenes Employing Mn(OAc) 3 ⋅ 2H 2 O as Acetoxy Source
Author(s) -
Sarkar Writhabrata,
Bhowmik Arup,
Mishra Aniket,
Vats Tripta Kumari,
Deb Indubhusan
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800398
Subject(s) - chemistry , cobalt , catalysis , manganese , combinatorial chemistry , metal , group (periodic table) , transition metal , medicinal chemistry , reaction conditions , stereochemistry , organic chemistry
A cobalt‐catalyzed sp 2 C−H acetoxylation of amides having 8‐aminoquinoline as a directing group has been achieved using manganese(III) acetate both as an oxidant and an acetoxy source. Operational simplicity, broad range of functional group tolerance, use of an earth abundant first row transition metal, and, most importantly, exploitation of an unprecedented acetoxy source are the key features. The method is scalable and does not require any additive. The mechanism of the reaction has been established by conducting a series of experiments.