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Copper Mediated Three‐Component Reactions of Alkynes, Azides, and Propargylic Carbonates: Synthesis of 5‐Allenyl‐1,2,3‐Triazoles
Author(s) -
Wu Feifei,
Zhou Wei,
Chen Kai,
Chen Wanzhi,
Liu Miaochang,
Wu Huayue
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800394
Subject(s) - chemistry , reagent , component (thermodynamics) , copper , alkyne , combinatorial chemistry , reaction conditions , organic chemistry , catalysis , physics , thermodynamics
A copper‐mediated one‐pot sequential reaction of terminal alkynes, azides, and propargylic carbonates is reported. The three component reaction occurs readily at room temperature to afford a 5‐allenyl‐1,2,3‐triazoles in high yields, providing a straightforward approach to 1,3,5‐trisubstituted triazoles using easily available Cu(I) reagent.