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Synthesis of Benzo[4,5]imidazo[2,1‐ b ]thiazole by Copper(II)‐Catalyzed Thioamination of Nitroalkene with 1 H ‐Benzo[ d ]imidazole‐2‐thiol
Author(s) -
Jana Sourav,
Chakraborty Amrita,
Shirinian Valerii Z.,
Hajra Alakananda
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800393
Subject(s) - chemistry , thiazole , nitroalkene , imidazole , catalysis , thiol , copper , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , enantioselective synthesis
A Copper(II)‐catalyzed thioamination of β ‐nitroalkene with 1 H ‐benzo[ d ]imidazole‐2‐thiol has been developed for the synthesis of benzo[4,5]imidazo[2,1‐ b ]thiazole derivatives. A variety of N ‐fused benzoimidazothiazole derivatives are obtained in high yields through successive C−N and C−S bond formations. This protocol is also applicable to β ‐substituted β ‐nitroalkenes to afford 2,3‐disubstituted benzoimidazothiazoles.