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Ruthenium‐Catalyzed Site‐selective Enone Carbonyl Directed ortho ‐C−H Activation of Aromatics and Heteroaromatics with Alkenes
Author(s) -
Bakthadoss Manickam,
Kumar Polu Vijay
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800376
Subject(s) - chemistry , enone , ruthenium , chalcone , catalysis , triple bond , stereoselectivity , double bond , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry
Abstract An efficient and versatile protocol for enone carbonyl directed ortho C−H activation of aromatics and heteroaromatics with alkenes for the construction of functionalized ortho ‐olefinated chalcone derivatives in excellent yields in a regio‐ and stereoselective fashion has been developed for the first time. This general protocol involves chelation assisted oxidative coupling in the presence of ruthenium catalyst through C−H bond activation. This protocol has been further emphasized by the exhibition of functional group tolerance.