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Cover Picture: Synthesis, Application and Kinetic Studies of Chiral Phosphite‐Oxazoline Palladium Complexes as Active and Selective Catalysts in Intermolecular Heck Reactions (Adv. Synth. Catal. 8/2018)
Author(s) -
Mazloomi Zahra,
Magre Marc,
Del Valle Efrem,
Pericàs Miquel A.,
Pàmies Oscar,
van Leeuwen Piet W. N. M.,
Diéguez Montserrat
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800331
Subject(s) - chemistry , oxazoline , palladium , heck reaction , trifluoromethanesulfonate , alkene , intermolecular force , phosphine , catalysis , medicinal chemistry , polymer chemistry , organic chemistry , molecule
The inside cover picture , provided by Oscar Pàmies, Piet W. N. M. van Leeuwen, Montserrat Diéguez and co‐workers, illustrates that chiral palladium complexes containing phosphite‐oxazoline ligands enable the effective asymmetric intermolecular Heck coupling of several substrates and triflate sources. The kinetic studies and the Hammett plot analysis indicate that the rate‐determining step is the migratory insertion of the alkene. From this finding the authors propose a hypothesis to explain the faster reaction rates of phosphite‐oxazoline systems compared to those of the phosphine analogues. Details can be found in the full paper on pages 1650–1664 (Z. Mazloomi, M. Magre, E. Del Valle, M. A. Pericàs, O. Pàmies, P. W. N. M. van Leeuwen, M. Diéguez, Adv. Synth. Catal . 2018 , 360 , 1650–1664; DOI: 10.1002/adsc.201701603).