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Cascade Formation of C 3 ‐Unsymmetric Spirooxindoles via PhI(OAc) 2 ‐Mediated Oxidative C−C/C−N Bond Formation
Author(s) -
Sun Jiyun,
Li Guangchen,
Zhang Guangtao,
Cong Ying,
An Xuechan,
ZhangNegrerie Daisy,
Du Yunfei
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800314
Subject(s) - hypervalent molecule , chemistry , oxidative phosphorylation , iodine , cascade , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , chromatography
A series of C 3 ‐unsymmetric spirooxindoles were achieved by reaction of diphenylmalonamides with PhI(OAc) 2 (PIDA) under metal‐free conditions. Control experiments suggest that the hypervalent iodine‐mediated reaction undergoes a cascade process involving an oxidative C−C bond formation preceeding an oxidative C−N bond formation.