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Indium(III)‐Catalyzed Hydration and Hydroalkoxylation of α,β‐Unsaturated Ketones in Aqueous Media
Author(s) -
Yun JinJin,
Zhi ManLing,
Shi WenXiao,
Chu XueQiang,
Shen ZhiLiang,
Loh TeckPeng
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800301
Subject(s) - chemistry , aqueous medium , indium , tetrahydrofuran , catalysis , aqueous solution , organic chemistry , combinatorial chemistry , solvent
The hydration of α,β‐unsaturated ketones with water proceeded efficiently in the presence of In(OTf) 3 (20 mol%) in aqueous media to afford synthetically versatile β‐hydroxyketones in moderate to good yields with good functional group compatibility. The method also can be extended to the hydroalkoxylation of α,β‐unsaturated ketones with various alcohols for the efficient synthesis of β‐alkoxyketones as well as tetrahydrofuran derivatives.