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Cobalt(III)‐Catalyzed Construction of Benzofurans, Benzofuranones and One‐Pot Orthogonal C−H Functionalizations to Access Polysubstituted Benzofurans
Author(s) -
Bera Sourav Sekhar,
Debbarma Suvankar,
Jana Sripati,
Maji Modhu Sudan
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800298
Subject(s) - chemistry , benzofuran , intramolecular force , amide , catalysis , electrophile , combinatorial chemistry , organic chemistry
Abstract Benzofuran and benzofuranone derivatives have been synthesized through exclusive 5‐ exo ‐ dig intramolecular hydroarylation using the amide‐directed, cost‐effective, high‐valent Cp*Co III ‐catalytic system. Challenging one‐pot, orthogonal C−H functionalizations using two different electrophiles are also reported to afford polysubstituted benzofurans. Several valuable functional group interconversions along with removal of the amide directing group provide a route to access several diversely functionalized benzofurans. The mechanistic study suggests a reversible cobaltation step is operative here.