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Palladium‐Catalyzed Domino Dehydrogenation/Heck‐Type Reactions of Carbonyl Compounds
Author(s) -
Le Bras Jean,
Muzart Jacques
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800258
Subject(s) - dehydrogenation , palladium , domino , catalysis , halide , chemistry , aryl , heck reaction , organic chemistry , combinatorial chemistry , photochemistry , medicinal chemistry , alkyl
This review covers those domino reactions that involve, at least, both palladium‐catalyzed dehydrogenation of carbonyl compounds and Heck‐type reactions. While the former occurs under Pd(II) catalysis, a Pd(0) or Pd(II) catalyst is required for the latter, depending on the nature of the (hetero)arylating agent, ArX or ArH, respectively. Regeneration of the Pd(II) species is assumed to proceed by either an oxidant or the aryl halide. Proposed mechanisms are described with, in some cases, personal comments.