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Modular 1,1′‐Ferrocenediyl‐cored P ‐Stereogenic Diphosphines: ′′JDayPhos′′ Series and its Use in Rhodium(I)‐Catalyzed Hydrogenation
Author(s) -
Poklukar Gašper,
Stephan Michel,
Mohar Barbara
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800255
Subject(s) - stereocenter , diphosphines , chemistry , rhodium , ferrocene , ligand (biochemistry) , asymmetric hydrogenation , catalysis , methylene , medicinal chemistry , stereochemistry , enantioselective synthesis , organic chemistry , biochemistry , receptor , electrode , electrochemistry
A novel ferrocene‐based P ‐stereogenic diphospine ligand series dubbed JDayPhos was developed, which rhodium(I) complexes of some of its members exhibited excellent enantioselectivity (up to >99% ee ) and high activity in asymmetric hydrogenation of β‐unsubstituted or ‐substituted itaconates and α‐methylene‐γ‐oxo‐carboxylates.