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Fe‐catalyzed dithiane radical induced C−S bond activation−addition to α, β‐unsaturated ketones
Author(s) -
Min Deng,
Yuan Xinyu,
Liu Teng,
Liu Jian,
Tang Shouchu
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800241
Subject(s) - chemistry , dithiane , thioether , organosulfur compounds , thioester , yield (engineering) , catalysis , combinatorial chemistry , organic chemistry , medicinal chemistry , sulfur , materials science , metallurgy , enzyme
An efficient and clean strategy to construct organosulfur compounds has been developed via a Fe‐catalyzed dithiane C−S bond activation/addition process with α, β‐unsaturated ketones. This C−S activation protocol exhibits excellent reactivities, and up to 92% yield of the corresponding thioether‐thioester derivatives could be obtained under the mild conditions, allowing the ready preparation of a number of synthetically valuable S‐linked conjugates.