Premium
An Industrial Perspective on Counter Anions in Gold Catalysis: Underestimated with Respect to “Ligand Effects”
Author(s) -
Schießl Jasmin,
Schulmeister Jürgen,
Doppiu Angelino,
Wörner Eileen,
Rudolph Matthias,
Karch Ralf,
Hashmi A. Stephen K.
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800233
Subject(s) - chemistry , catalysis , homogeneous , substrate (aquarium) , ligand (biochemistry) , combinatorial chemistry , reactivity (psychology) , ion , dominance (genetics) , organic chemistry , thermodynamics , medicine , biochemistry , physics , oceanography , receptor , alternative medicine , pathology , gene , geology
Abstract The conversion of a variety of well‐known test reactions, representing the key reactivity patterns of gold catalysis, were analyzed by GC and 1 H NMR. The study is focused on establishing of a strategical approach for the consideration of ligand influence and counter anion influence during the catalyst optimization including an industrial perspective. The study shows a dominance of the counter anion, a dominance which up to now has been neglected in most of the routine screenings. In addition, a drastic substrate‐dependency became obvious, even a marginal variation of the substrate already could strongly effect the catalytic activity and change the optimal counter anion or ligand. Based on the collected data a strategic concept for an efficient screening for a specific substrate is introduced, this concept can serve as an important guideline for catalyst optimization in homogeneous gold catalysis.