CuI‐Catalyzed Selective 3‐Alkylation of Indoles with  N ‐Tosylhydrazones and the I 2 ‐Mediated Further Cyclization to Chromeno[2,3‐ b ]Indoles | Zendy

Miao ChunBao | Zendy; Sun YanFang | Zendy; Wu He | Zendy; Sun XiaoQiang | Zendy; Yang HaiTao | Zendy

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CuI‐Catalyzed Selective 3‐Alkylation of Indoles with N ‐Tosylhydrazones and the I 2 ‐Mediated Further Cyclization to Chromeno[2,3‐ b ]Indoles

Author(s) -

Miao ChunBao,

Sun YanFang,

Wu He,

Sun XiaoQiang,

Yang HaiTao

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201800206

Subject(s) - chemistry , alkylation , indole test , catalysis , organic chemistry , medicinal chemistry , stereochemistry , combinatorial chemistry

The CuI‐catalyzed reaction of indoles with N ‐tosylhydrazones derived from the ortho ‐ /para ‐hydroxybenzaldhydes affords selectively the C ‐3 alkylated products rather than the N ‐alkylated products. In addition, the I 2 ‐mediated cyclization of the generated C ‐3 alkylated products allows the concise synthesis of chromeno[2,3‐ b ]indole derivatives.

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