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Recent Advances in the Construction of C–N Bonds Through Coupling Reactions between Carbon Radicals and Nitrogen Radicals
Author(s) -
Luo Junfei,
Wei WenTing
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800205
Subject(s) - radical , chemistry , nitrogen , coupling reaction , carbon fibers , photochemistry , coupling (piping) , organic chemistry , catalysis , materials science , composite number , composite material , metallurgy
Abstract C−N bonds are widely found in natural products, medicinal molecules and multifunctional materials. In recent years, the construction of C−N bonds through a radical coupling reaction between carbon‐centered radicals with nitrogen‐centered radicals has emerged as a frontier area in organic chemistry. This review summarizes the recent advances (especially those after 2012) in radical coupling reactions that facilitate the formation of C−N bonds. The main achievements on this area are presented according to the pattern of the nitrogen‐centered radicals generated. Selected examples of substrates are listed and special attention is paid to the reaction mechanisms. Moreover, a personal outlook is described at the end.