Palladium‐Catalyzed Hydroalkylation of Alkynes with Cyclopropanols: Access to γ,δ‐Unsaturated Ketones | Zendy

Liu Hao | Zendy; Fu Zhiyuan | Zendy; Gao Shang | Zendy; Huang Yue | Zendy; Lin Aijun | Zendy; Yao Hequan | Zendy

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Palladium‐Catalyzed Hydroalkylation of Alkynes with Cyclopropanols: Access to γ,δ‐Unsaturated Ketones

Author(s) -

Liu Hao,

Fu Zhiyuan,

Gao Shang,

Huang Yue,

Lin Aijun,

Yao Hequan

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201800200

Subject(s) - chemistry , catalysis , palladium , selectivity , deuterium , solvent , atom economy , atom (system on chip) , organic chemistry , medicinal chemistry , physics , quantum mechanics , computer science , embedded system

A palladium‐catalyzed hydroalkylation of alkynes with cyclopropanols has been developed. This reaction provided a straightforward way to the synthesis of γ,δ‐unsaturated ketones in moderate to good yields, exhibiting high atom economy and Z/E selectivity. Deuterated tri‐substituted alkenes could also be expediently produced by using deuterium oxide as a co‐solvent.

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