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Palladium‐Catalyzed Hydroalkylation of Alkynes with Cyclopropanols: Access to γ,δ‐Unsaturated Ketones
Author(s) -
Liu Hao,
Fu Zhiyuan,
Gao Shang,
Huang Yue,
Lin Aijun,
Yao Hequan
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800200
Subject(s) - chemistry , catalysis , palladium , selectivity , deuterium , solvent , atom economy , atom (system on chip) , organic chemistry , medicinal chemistry , physics , quantum mechanics , computer science , embedded system
A palladium‐catalyzed hydroalkylation of alkynes with cyclopropanols has been developed. This reaction provided a straightforward way to the synthesis of γ,δ‐unsaturated ketones in moderate to good yields, exhibiting high atom economy and Z/E selectivity. Deuterated tri‐substituted alkenes could also be expediently produced by using deuterium oxide as a co‐solvent.