Conjugate Additions of Amines to Maleimides via Cooperative Catalysis | Zendy

Uno Brice E. | Zendy; Deibler Kristine K. | Zendy; Villa Carlos | Zendy; Raghuraman Arjun | Zendy; Scheidt Karl A. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Conjugate Additions of Amines to Maleimides via Cooperative Catalysis

Author(s) -

Uno Brice E.,

Deibler Kristine K.,

Villa Carlos,

Raghuraman Arjun,

Scheidt Karl A.

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201800160

Subject(s) - chemistry , conjugate , combinatorial chemistry , amine gas treating , lewis acids and bases , conjugated system , catalysis , lithium (medication) , chemoselectivity , organic chemistry , polymer , mathematical analysis , mathematics , medicine , endocrinology

A cooperative system comprising of a lithium Lewis acid and amine base significantly enhances the rate of the conjugate addition of a wide array of amines to maleimides. This operationally simple, scalable method provides mono‐addition products in high yields and purity. This conjugation was successfully applied to the kinase inhibitor crizotinib in a chemoselective ligation to create novel fluorescent probe.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research