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DBU‐Catalyzed Selective N ‐Methylation and N ‐Formylation of Amines with CO 2 and Polymethylhydrosiloxane
Author(s) -
Li Gang,
Chen Jie,
Zhu DaoYong,
Chen Ye,
Xia JiBao
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800140
Subject(s) - formylation , chemistry , catalysis , reagent , organic chemistry , methylation , organocatalysis , medicinal chemistry , enantioselective synthesis , biochemistry , gene
We describe herein an efficient organocatalytic system for the selective N ‐methylation and N ‐formylation of amines with carbon dioxide (CO 2 ) as a sustainable C1 feedstock and polymethylhydrosiloxane (PMHS) as a cost‐effectvie reducing reagent. High‐yielding N ‐methylation products are obtained with low catalyst loading (1%) of DBU. Selective N ‐formylation of amines is achieved using the same catalytic system at a lower reaction temperature.