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Synthesis of Monofluoromethylthioesters from Aldehydes
Author(s) -
Guo ShiHuan,
Wang MengYue,
Pan GaoFei,
Zhu XueQing,
Gao YaRu,
Wang YongQiang
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800136
Subject(s) - chemistry , scope (computer science) , substrate (aquarium) , combinatorial chemistry , reaction conditions , surface modification , functional group , nanotechnology , biochemical engineering , organic chemistry , catalysis , computer science , oceanography , polymer , materials science , programming language , geology , engineering
A direct and efficient approach to the synthesis of monofluoromethylthioesters from aldehydes has been developed. The synthetic method features mild reaction conditions, good tolerance of functional groups, a broad substrate scope, and especially no metal involved in the reaction. The approach has the potential to be an important tool for the late‐stage functionalization of advanced synthetic intermediates, and may find many applications in medicinal chemistry.