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Rhodium‐Catalyzed Direct and Selective ortho C−H Chalcogenation of N ‐(Hetero)aryl‐7‐azaindoles
Author(s) -
Vats Tripta Kumari,
Mishra Aniket,
Deb Indubhusan
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800090
Subject(s) - chemistry , rhodium , regioselectivity , trifluoromethanesulfonate , aryl , catalysis , combinatorial chemistry , molecule , stereochemistry , organic chemistry , alkyl
Rhodium catalyzed synthesis of chalcogenated N ‐aryl‐7‐azaindoles/azaindolines has been developed through N‐directed ortho C sp 2 −H activation in presence of silver triflate and silver carbonate in 1,4‐dioxane using dichalcogenides. We have established this methodology as being efficient, highly regioselective and scalable, having a broad substrates scope. Through this route, a range of substrates have furnished thiolation and selenylation of azaindoles and azaindolines in good to excellent yields. These molecules could have potential application in biological and/or material science.