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Asymmetric Brominative Dearomatization of Naphthols Catalyzed by Chiral Copper Complexes
Author(s) -
Wang YiFeng,
Shao JuanJuan,
Wang Biao,
Chu MingMing,
Qi SuoSuo,
Du XiaoHua,
Xu DanQian
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800067
Subject(s) - chemistry , stereocenter , enantioselective synthesis , diphenylamine , catalysis , yield (engineering) , oxazoline , copper , combinatorial chemistry , organic chemistry , stereochemistry , medicinal chemistry , materials science , metallurgy
A fast and highly enantioselective brominative dearomatization of naphthols catalyzed by diphenylamine‐linked bis(oxazoline)‐Cu(OTf) 2 complexes has been developed. The corresponding products of chiral naphthalenones bearing a Br‐containing tetrasubstituted stereogenic center could be obtained with good to excellent enantioselectivities (up to 95% ee ) in excellent yields (up to 97% yield) within short reaction times.