Asymmetric Brominative Dearomatization of Naphthols Catalyzed by Chiral Copper Complexes | Zendy

Wang YiFeng | Zendy; Shao JuanJuan | Zendy; Wang Biao | Zendy; Chu MingMing | Zendy; Qi SuoSuo | Zendy; Du XiaoHua | Zendy; Xu DanQian | Zendy

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Asymmetric Brominative Dearomatization of Naphthols Catalyzed by Chiral Copper Complexes

Author(s) -

Wang YiFeng,

Shao JuanJuan,

Wang Biao,

Chu MingMing,

Qi SuoSuo,

Du XiaoHua,

Xu DanQian

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201800067

Subject(s) - chemistry , stereocenter , enantioselective synthesis , diphenylamine , catalysis , yield (engineering) , oxazoline , copper , combinatorial chemistry , organic chemistry , stereochemistry , medicinal chemistry , materials science , metallurgy

A fast and highly enantioselective brominative dearomatization of naphthols catalyzed by diphenylamine‐linked bis(oxazoline)‐Cu(OTf) 2 complexes has been developed. The corresponding products of chiral naphthalenones bearing a Br‐containing tetrasubstituted stereogenic center could be obtained with good to excellent enantioselectivities (up to 95% ee ) in excellent yields (up to 97% yield) within short reaction times.

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