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Visible‐Light‐Induced Difluoropropargylation Reaction with Benzothiazoline as a Reductant
Author(s) -
Chen Jingzhi,
Huang Wenhao,
Li Ying,
Cheng Xu
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800066
Subject(s) - chemistry , silylation , moiety , reagent , reactivity (psychology) , photochemistry , visible spectrum , click chemistry , catalysis , combinatorial chemistry , organic chemistry , medicine , physics , alternative medicine , optoelectronics , pathology
The difluoropropargyl group is a useful moiety for biological applications such as in vivo click chemistry for molecular imaging techniques. Silyl‐protected bromodifluoropropyne is an important difluoropropargylation reagent with previously unexplored radical reactivity. Herein, we report visible‐light‐induced thiyl‐radical‐catalyzed hydrodifluoropropargylation reactions between silyl‐protected bromodifluoropropyne and alkenes in the presence of benzothiazoline as a critical reductant.