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Front Cover Picture: Organocatalytic Enantioselective Friedel–Crafts Alkylation/Lactonization Reaction of Hydroxyindoles with Methyleneoxindoles (Adv. Synth. Catal. 5/2018)
Author(s) -
Xiao Mengjie,
Xu Dengfeng,
Liang Weihong,
Wu Wenyu,
Chan Albert S. C.,
Zhao Junling
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201800010
Subject(s) - chemistry , squaramide , cinchona , enantioselective synthesis , regioselectivity , friedel–crafts reaction , alkylation , organocatalysis , indole test , medicinal chemistry , catalysis , organic chemistry , stereochemistry
The front cover picture , provided by Junling Zhao and co‐workers, illustrates an organocatalytic enantioselective protocol for the Friedel–Crafts alkylation/lactonization reaction of hydroxyindoles with methylene oxindoles. This reaction was efficiently catalyzed by a Cinchona alkaloid‐derived squaramide catalyst, affording the corresponding pyrrolodihydrocoumarin derivatives in moderate to high yields with high enantioselectivities. More importantly, this paper shows an efficient strategy for the regioselective functionalization of the indole benzene positions. Details can be found in the full paper on pages 917–924. (M.‐J. Xiao, D.‐F. Xu, W.‐H. Liang, W.‐Y. Wu, A. S. C. Chan, J.‐L. Zhao, Adv. Synth. Catal . 2018 , 360 , 917–924; DOI: 10.1002/adsc.201701089)