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One‐pot Construction of Difluorinated Pyrrolizidine and Indolizidine Scaffolds via Copper‐Catalyzed Radical Cascade Annulation
Author(s) -
Wang Xiaoyang,
Li Miao,
Yang Yanyan,
Guo Minjie,
Tang Xiangyang,
Wang Guangwei
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701643
Subject(s) - chemistry , annulation , pyrrolizidine , indolizidine , cascade , catalysis , copper , amine gas treating , combinatorial chemistry , organic chemistry , stereochemistry , alkaloid , chromatography
A convenient approach to the synthesis of diverse difluorinated nitrogen‐containing polycycles via a copper‐catalyzed radical cascade annulation of amine‐containing olefins and ethyl bromodifluoroacetate was developed. Three new bonds, including a C s p 3−CF 2 and two C−N bonds, are forged simultaneously in this strategy. Through this strategy, a series of difluorinated pyrrolizidine and indolizidine derivatives have been conveniently synthesized in good yields.