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Copper‐Catalyzed Enantioselective Synthesis of β‐Amino Alcohols Featuring Tetrasubstituted Tertiary Carbons
Author(s) -
Tian Lan,
Gong Liang,
Zhang Xia
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701613
Subject(s) - chemistry , enantioselective synthesis , copper , catalysis , enantiomer , combinatorial chemistry , organic chemistry , enantiomeric excess , alcohol
Abstract Here we report a copper‐catalyzed asymmetric propargylic substitution reaction to prepare tetrasubstituted β‐amino‐β‐ethynyl alcohols in high yields and with enantiomeric ratio ( er ) up to 94:6. This transformation generates tetrasubstituted tertiary carbons by utilizing stable cyclic carbonates and amines as substrates, economical copper catalysts, and easily accessible ligands.