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Metal‐Free Multicomponent Reaction for Synthesis of 4,5‐Disubstituted 1,2,3‐( NH )‐Triazoles
Author(s) -
Wu GuangLong,
Wu QinPei
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701587
Subject(s) - chemistry , sulfur , sodium azide , azide , domino , substrate (aquarium) , salt (chemistry) , coupling reaction , metal , organic chemistry , combinatorial chemistry , catalysis , oceanography , geology
A metal‐free domino reaction was developed for efficient synthesis of 4,5‐disubstituted 1,2,3‐( NH )‐triazoles by sequentially coupling sulfur salts with aldehydes and sodium azide. In the presence of L ‐proline, olefinic sulfur salt intermediates rather than epoxides are formed in situ via the coupling of sulfur salts with aldehydes and cyclize with azide ion. This process features mild conditions, high efficiency, commercially available starting materials, and wide substrate scope.