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Palladium‐Catalyzed Benzodifluoroalkylation of Alkynes: A Route to Fluorine‐Containing 1,1‐Diarylethylenes
Author(s) -
Liang Junqing,
Huang Guozhi,
Peng Peng,
Zhang Tianyu,
Wu Jingjing,
Wu Fanhong
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701569
Subject(s) - synthon , chemistry , palladium , catalysis , stereoselectivity , fluorine , combinatorial chemistry , organic chemistry
A palladium(0)‐catalyzed three‐component reaction of 2‐iodo‐2,2‐difluoroacetophenones, alkynes and arylboronic acids is introduced for the synthesis of 1‐benzoyldifluoromethyl‐2,2‐diphenylethylenes in good yields and with excellent stereoselectivity. The 1‐benzoyldifluoromethyl‐2,2‐diphenylethylene products synthesized through a radical reaction process are versatile synthons for the construction of various fluorine‐containing compounds, which have antiproliferative activity on human tumor cells.