Palladium‐Catalyzed Benzodifluoroalkylation of Alkynes: A Route to Fluorine‐Containing 1,1‐Diarylethylenes | Zendy

Liang Junqing | Zendy; Huang Guozhi | Zendy; Peng Peng | Zendy; Zhang Tianyu | Zendy; Wu Jingjing | Zendy; Wu Fanhong | Zendy

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Palladium‐Catalyzed Benzodifluoroalkylation of Alkynes: A Route to Fluorine‐Containing 1,1‐Diarylethylenes

Author(s) -

Liang Junqing,

Huang Guozhi,

Peng Peng,

Zhang Tianyu,

Wu Jingjing,

Wu Fanhong

Publication year - 2018

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201701569

Subject(s) - synthon , chemistry , palladium , catalysis , stereoselectivity , fluorine , combinatorial chemistry , organic chemistry

A palladium(0)‐catalyzed three‐component reaction of 2‐iodo‐2,2‐difluoroacetophenones, alkynes and arylboronic acids is introduced for the synthesis of 1‐benzoyldifluoromethyl‐2,2‐diphenylethylenes in good yields and with excellent stereoselectivity. The 1‐benzoyldifluoromethyl‐2,2‐diphenylethylene products synthesized through a radical reaction process are versatile synthons for the construction of various fluorine‐containing compounds, which have antiproliferative activity on human tumor cells.

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