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Copper‐Catalyzed Cross‐Coupling of Secondary α‐Haloamides with Terminal Alkynes: Access to Diverse 2,3‐Allenamides
Author(s) -
Lv Yunhe,
Pu Weiya,
Zhu Xueli,
Zhao Tiantian,
Lin Feifei
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701556
Subject(s) - chemistry , terminal (telecommunication) , scope (computer science) , substrate (aquarium) , coupling (piping) , catalysis , copper , complement (music) , combinatorial chemistry , organic chemistry , computer science , programming language , telecommunications , metallurgy , biochemistry , oceanography , materials science , phenotype , complementation , gene , geology
A copper‐catalyzed C( sp )−C( sp 3 ) cross‐coupling of terminal alkynes with readily available secondary α‐haloamides for the efficient synthesis of 2,3‐allenamides is realized. The methodology is characterized by its wide substrate scope, which makes it an important complement to traditional methods for synthesizing allenes. A mechanism involving an alkynylcopper species is proposed.