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Access to Amidines and Arylbenzimidazoles: Zinc‐Promoted Rearrangement of Oxime Acetates
Author(s) -
Zhu Zhongzhi,
Cen Jinghe,
Tang Xiaodong,
Li Jianxiao,
Wu Wanqing,
Jiang Huanfeng
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701490
Subject(s) - chemistry , oxime , zinc , combinatorial chemistry , medicinal chemistry , organic chemistry
An efficient and straightforward zinc‐promoted rearrangement of oxime acetates with arylamines for the synthesis of amidines has been developed under mild conditions. This process involves N−O/C−C bond cleavages and C−C/C−N bond formations. Various oxime acetates and arylamines are suitable for this transformation. Furthermore, diverse arylbenzimidazoles could also be prepared through simple one‐pot procedure.

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