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Diastereoselective Electrophilic Trifluoromethylthiolation of Chiral Oxazolidinones: Access to Enantiopure α‐SCF 3 Alcohols
Author(s) -
Chachig Hélène,
Kondrashov Evgeniy V.,
Cahard Dominique
Publication year - 2018
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201701474
Subject(s) - enantiopure drug , chemistry , electrophile , lithium (medication) , imide , stereochemistry , organic chemistry , combinatorial chemistry , enantioselective synthesis , catalysis , medicine , endocrinology
Lithium imide enolates featuring Evans’ chiral oxazolidinone auxiliary were involved in diastereoselective α‐trifluoromethylthiolation with electrophilic SCF 3 donors. Diastereopure products were isolated and converted to enantiopure α‐SCF 3 alcohols without racemisation.
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